Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization. Li Di, Edward H Kerns

Drug-Like-Properties-Concepts.pdf
ISBN: 9780128010761 | 580 pages | 15 Mb

• Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
• Li Di, Edward H Kerns
• Page: 580
• Format: pdf, ePub, fb2, mobi
• ISBN: 9780128010761
• Publisher: Elsevier Science

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Overview

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods

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A Changing World: Patriotism Against a Globalist Agenda. Cesar Vidal

A-Changing-World.pdf
ISBN: 9781950604067 | 384 pages | 10 Mb

• A Changing World: Patriotism Against a Globalist Agenda
• Cesar Vidal
• Page: 384
• Format: pdf, ePub, fb2, mobi
• ISBN: 9781950604067
• Publisher: Agustin Agency

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Broken Throne: A Red Queen Collection . Victoria Aveyard

Broken-Throne-A-Red-Queen.pdf
ISBN: 9780062940209 | 480 pages | 12 Mb

• Broken Throne: A Red Queen Collection
• Victoria Aveyard
• Page: 480
• Format: pdf, ePub, fb2, mobi
• ISBN: 9780062940209
• Publisher: HarperCollins Publishers

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Return once more to the deadly and dazzling world of Red Queen in this Barnes & Noble exclusive edition of Broken Throne, a beautifully designed, must-have companion to the chart-topping series. In this special Barnes & Noble edition, readers will also gain a unique look at the royal House Calore in an elaborate, full-color, poster-sized family tree. The perfect addition to the #1 New York Times bestselling Red Queen series, this gorgeously designed package features three brand-new novellas, two previously published novellas, Steel Scars and Queen Song, and never-before-seen maps, flags, bonus scenes, journal entries, and much more exclusive content. Fans will be delighted to catch up with beloved characters after the drama of War Storm and be excited to hear from brand new voices as well. This stunning collection is not to be missed!

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ANÉCDOTAS DE ENFERMERAS de ELISABETH G. IBORRA

Ficha técnica

• ANÉCDOTAS DE ENFERMERAS
• ELISABETH G. IBORRA
• Número de páginas: 336
• Idioma: CASTELLANO
• Formatos: Pdf, ePub, MOBI, FB2
• ISBN: 9788466348270
• Editorial: DEBOLSILLO (PUNTO DE LECTURA)
• Año de edición: 2019

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Historias inverosímiles pero confirmadas por decenas de enfermeras de distintas comunidades que no se han conocido nunca entre sí. Este libro es la demostración de que las leyendas urbanas, en enfermería, se quedan muy cortas con respecto a la realidad. La imaginación de la mente colectiva no llega a la altura de las anécdotas que las enfermeras de este país viven a diario en los centros sanitarios: los enfermos y sus familiares que acuden a estos centros parecen ir en un estado de nerviosismo y despiste que les lleva a protagonizar hazañas verdaderamente surrealistas.

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WILLIAMS. TRATADO DE ENDOCRINOLOGÍA, 13ª ED. de S MELMED

Ficha técnica

• WILLIAMS. TRATADO DE ENDOCRINOLOGÍA, 13ª ED.
• S MELMED
• Número de páginas: 1936
• Idioma: CASTELLANO
• Formatos: Pdf, ePub, MOBI, FB2
• ISBN: 9788491131014
• Editorial: S.A. ELSEVIER ESPAÑA
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Overview

Durante más de sesenta y cinco años ha sido la obra de referencia de esta especialidad, aportando sólidos conocimientos sobre todos los aspectos de los trastornos del sistema endocrino, tanto en adultos como en pacientes pediátricos.

La décimotercera edición incorpora nuevos capítulosy actualiza en profundad numerosos temas, con objeto de dar cobertura a los conocimientos más avanzados sobre diabetes, síndrome metabólico, obesidad, enfermedades tiroideas, trastornos testiculares y muchas otras alteraciones, y de ayudar a proporcionar la merjor atención a los pacientes.

El reto de esta nueva edición es seguir siendo una referencia en el ámbito de la endocrinología, manteniendo unenfoque integrador que cubre las necesidades tanto de especialistas en endocrinología como en medicina interna.

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